The most statistically reliable method of NLS-research in case of urinary bladder tumors is an ultramicroscopic research with the usу of spectral-entropy analysis. Such method provides the detection of the tumor less than 3 mm., specifies its localization and in case of its invasive form it allows specifying its proportion in relation to adjacent organs and tissues. It is possible to examine the layers of bladder wall in all patients when using 3D NLS-ultramicroscopic research.

     We use spectral-entropy analysis in case of any process localization in urinary bladder after performance of ultramicroscopic research. Only endocavitary ultramicroscopic research is the most effective method for examination of all tumor aniages in case of multicentric growth.

    Common 2D NLS-research (which was put high hopes on) did not obtain widespread use in our country. Such method allows good visualization of superficial formations though relatively large ones (from 6-8 mm).

     In case of deep invasion it is not always possible to estimate the exterior contour of the tumor. These peculiarities lower the effectiveness of 2D NLS-graphy method in detection of invasion depth into the bladder wall.

    At the present time we are able to use extensively NLS-research of urinary bladder tumors with 3D reconstruction. The method allows visually presentation of the tumor and its correlation with surrounding tissues when making decision on choosing of surgical procedures type, and it allows storing the information in digital format. Information storing provides the possibility for attending doctors to subsequently review the whole 3D information block which gives more objectiveness to 3D NLS-research.