The Non-linear Diagnostic System (NLS)has been extensively used lately and are gaining ever growing popularity. Even in the few cases, where the clinical symptoms look very typical the NLS diagnostics method provides extra information about the extent of the affection and allows to consider a prognosis. In most cases it is of vital importance for diagnostics and subsequently for the right choice of treatment.

    Non-linear analysis was originally employed in organic chemistry to determine the composition of complex compounds.

    Sviatoslav Pavlovich Nesterov who introduce a trigger sensor in 1988 and thus framed the concept is acceptably considered as a originator of NLS-diagnostics devices (metatron) Active work was immediately started to develop and improve the NLS-diagnostics systems. Clinical testing of the early equipment took the period from 1990 through 1995. The late 90s saw a fast growth of commercial production of the device and a sudden surge in the quality of the results produced.

    The non-linear diagnostics is still in its developing stage. (2003) The diagnostic techniques are improving so fast, that the system version have to be updated every six months. Due to the introduction of some of new devices equipped with digital trigger sensor, the NLS-diagnostics has become not only far more time-efficient but also quiet different in terms of quality. It is obvious that some runtime techniques, for instance tree-dimensional visualization of investigation results will soon become a daily practice. The negative testing is just an example of a ready implementation. The method is employed so widely that we should rather speak about a definite rang of indication for its use than just about popularisation.

    Unlike NMR and computer tomography, the NLS-analysis does not need strong fields. The method seems to have good prospect for metabolism studies, particularly on a cellular level.

    The NLS-method advances along the path not only of technical innovation but also of new application. Some minor surgical operations, biopsy for one, have been long monitored using ultrasound, fluoroscopy or computer tomography. Today we have opportunity to have biopsy monitored by NLS. By the way, many surgeons focus on using this method to assist major surgeries.

     The cost of equipment for NLS-diagnostics is still very low as compared to some other hardware-based methods. This is supposed to promote more extensive use of the method in countries with low living standards. Of all methods of hardware-based diagnostics the NLS provides representations most proximate to the pathologicoanatomic picture. This feature of the method along with its harmlessness, promotes rapid development of the NLS-diagnostics.

     Now more and more devices use the technology of NLS-diagnostics, such as 3D-NLS and Bioplasm-NLS. They are playing a great role on people's health problems.