Timely and accurate diagnostics of pancreatic diseases, without which efficient treatment is not possible, is one of the main goals of a modern gastroenterology. It is determined by increasing of disease incidence and difficulties in a differential diagnostics due to absence of pathognomonic clinical symptoms, especially in the early stages of an illness. The difficult is differential diagnostics between pancreas head cancer and a chronic pseudo-tumor-like pancreatitis that sometimes result in complications requiring surgical interventions. These diseases may look like stomach and duodenum ulcer, pylorus stenosis and be accompanied by gastrointestinal hemmorhage and acute pain in superior parts of stomach. Chronic pancreatitis is diagnosed in 0.2-6.8% of adults. It is diagnosed in 6-8% of all digestive organs diseases. Examination of patients suffering from pancreas pathologies must ensure accurate diagnosing allowing to choose adequate tactics of treatment in proper time.

    Choosing of diagnostic method depends on its availability, informativity, possibility of graphic registration of acquired data, safety and affordability. At the present moment neither method of clinical and hardware examination cannot solve problems of modern diagnostics of pancreas pathologies independently.

    Leading position in detection of pancreas pathologies is taken by radiological methods, although their accuracy is far from perfect.

    Recently appeared NLS-diagnostics method allows to acquire sufficiently accurate information about parenchyma’s and pancreatic ducts system’s condition. But until now two-dimensional NLS-graphy leaves unsolved certain issues related to spatial relations of examined structures and character of affection; in theory this issues may be addressed by three-dimensional NLS-graphy with spectral-entropic analysis (SEA) of tissues.

    So, one of the most prospective directions of NLS-diagnostics development is a method of three-dimensional reconstruction of NLS-image by metatron 4025, allowing to visualize projections hidden for two-dimensional scanning and to carry out anatomical reconstruction of researched area. This method allows to see any projection of acquired image, select separate parts of it and operate the data interactively using rotation and scaling of researched structures.

    Three-dimensional image rendering improves visualization in revealing of pancreas structure changes. Superficial multidimensional image reconstruction with adjustable transparency feature improves quality of visualization of both internal structure of revealed neoplasm and its shape and contours. In case of duct system (common bile duct and major pancreatic duct) dilation this mode allows to distinguish external contour of duct wall from neighboring tissues and internal surface of wall from a cavity content, to monitor structure of duct wall in the investigated area.

    Multi-plane multidimensional reconstruction of an image with segmentation feature allows to localize and define size of a neoplasm in pancreas parenchyma and to evaluate borders with surrounding tissues, ducts and vessels.

    Multi-plane multidimensional reconstruction of an image with color-coded methods allows to carry out three-dimensional reconstruction of tissues and vessels that reveals convincing signs of affection.

    Thus application of three-dimensional NLS-graphy with SEA allows to:

– carry out more precise differential diagnostics between benign and malignant nature of detected pancreatic neoplasms;

– define clearly indications for extended diagnostics (evaluation of spectral similarity with oncological markers) in order to exclude tumorous affection of pancreas;

– exclude in some cases duplicating radiologic methods (MSCT and MRCG), which optimizes diagnostic algorithm of patients examination;

– decrease a risk of complications development, related to using of invasive methods of diagnostics (ERCPG, needle biopsy);

– choose treatment tactics in proper time;

– ensure dynamic monitoring in a diagnostic department for patients from pancreas tumor development risk group.

    In order to exclude a possibility of tumorous process development in pancreas all patients with diagnosed chronic pseudo-tumor-like pancreatitis and moderate increasing of tumor markers level are recommended for dynamic monitoring in a diagnostic department.