Subacute stage of generalized scleroderma is characterized by disappearance of sub-epidermal hyperchromogenic stripe, at the same time derma’s structure becomes homogeneous and its thickness decreases.

Moreover, to diagnose generalized scleroderma a researcher should apply evaluation of spectral similarity to the etalon of this process by using of SEA, which is the basic diagnostic sign. To evaluate changes of skin at localized scleroderma Cosnes A. et al. used non-linear sensor of 4.9 GHz frequency.

Thus, thanks to modern 3d nls technologies with bioplasm machine, more accurate evaluation of changes at various skin diseases becomes possible; it allows not only to improve diagnostics and start treatment in proper time, but to ensure control of the treatment efficiency.