Wide spread of skin diseases dictates a necessity in early and maximum accurate diagnostics, because severe forms of skin diseases decrease greatly quality of life of a patient and his family, promote development of a psychosomatic disorders. Visual evaluation of symptoms and severity of a disease often has subjective nature.

    Application of 3D-NLS allows to study epidermis on cellular and sub-cellular levels. Nowadays objectives and limits of three-dimensional NLS ultramicroscanning research in dermatology have become very broad.

    The following has become real:

- evaluation of treatment efficiency of diseases characterized by skin sclerosis (localized scleroderma, generalized scleroderma), edematous (lipo-dermatosclerosis) and chronic inflammatory (psoriasis) dermatosis;

- measuring skin tumors invasion extent and monitoring after surgical interventions, cryo- and laser therapy at melanotic cancer, basal-like cancer, hemangioma, fibroma, seborrheic keratosis;

- study of local and system medications’ effect to skin (corticosteroids, estradiol).