In a healthy skin there are small areas, which are located in derma and correspond to hair follicles, vessels and sebaceous glands. Hypoderm at NLS-grpahy is represented as hypochromogenic and achromogenic layer, because mainly it consists of relatively homogeneous fat tissue. In this layer more chromogenic strips may be found, which represent connective interseptums.

    Analysis showed that 3D-NLS often applied at various skin oncologic diseases. To study skin tumors both two-dimensional and three-dimensional NLS-graphy may be applied. In majority of cases tumors are represented as areas of increased chromogeneity, more or less separated from derma. It is impossible to define histological character of a tumor on the basis of NLS-graphy only.

    For differential diagnostics of such skin tumors as hemangioma or melanoma, modes of ultramicroscanning together with spectral-entropic analysis (SEA) may be successfully applied.