Metatron 4025 Hunter system has axial resolution of 30 µm. Application of this device allows to study epidermis on cellular and sub-cellular levels.

Nowadays objectives and limits of three-dimensional NLS-ultramicroscanning research in dermatology have become very broad.

The following has become real:

– evaluation of treatment efficiency of diseases characterized by skin sclerosis (localized scleroderma, generalized scleroderma), edematous (lipo-dermatosclerosis) and chronic inflammatory (psoriasis) dermatosis;

– measuring skin tumors invasion extent and monitoring after surgical interventions, cryo- and laser therapy at melanotic cancer, basal-like cancer, hemangioma, fibroma, seborrheic keratosis;

– study of local and system medications’ effect to skin (corticosteroids, estradiol).

In accordance with a methodology the NLS-ultramicroscanning diagnostics of skin diseases must be carried out by comparing of affected area with healthy skin at counterlateral homological area.

At NLS-graphy with use of non-linear sensors of 4.9 GHz frequency, normal skin is represented by three layers: epidermis, derma and subcutaneous tissue. Regional and age-related peculiarities of skin thickness are conditioned by derma thickness mainly, which depends in the first place on collagen content in it.

It is considered that at NLS-study with sensor frequency of 1.4 GHz, normal epidermis is visualized poorly, because real thickness of epidermis is 0.02 – 0.5 mm, which is a limit of resolution for system of this class.

According to El Gammal S. et al. who used metatron 4025 hunter system with non-linear sensor of 4.9 GHz operating frequency, horny and malpighian layers of epidermis may be differentiated.

Super-high-frequency non-linear sensors allow to research more superficial papillary layer and underlying reticular layer of derma, The latter is characterized by more homogeneous structure.