Analysis of references showed that NLS-research of skin often applied at various oncologic diseases. To study skin tumors both two-dimensional and three-dimensional NLS-graphy may be applied. In majority of cases tumors are represented as areas of increased chromogeneity, more or less separated from derma. It is impossible to define histological character of a tumor on the basis of NLS-graphy only.

For differential diagnostics of such skin tumors as hemangioma or melanoma, modes of ultramicroscanning together with spectral-entropic analysis (SEA) may be successfully applied.

Using NLS-graphy makes possible to study malignant melanomas. Melanomas at NLS-research are spindle shaped, quire homogeneous in structure and clearly separated from surrounding tissues. We noted high precision in evaluation of neoplasms’ size, which were confirmed by comparison of data acquired with NLS-study of a tumor before surgical intervention and by histological tests after operation. According to other data, despite good visualization of a tumor at NLS-graphic study, the major problem is to distinguish tumor parenchyma from surrounding inflammatory infiltrate, because they look like single hyperchromogenic structure. Thus size of some tumors may be overstated at NLS-study. As studies of Ulrich J. et al. show, accuracy of tumor size evaluation increases greatly if we exclude from analysis tumors with extensive inflammatory infiltrate or nevus-associated melanomas when we apply SEA.

Thanks to modern NLS-technologies with biophilia tracker, more accurate evaluation of changes at various skin diseases becomes possible; it allows not only to improve diagnostics and start treatment in proper time, but to ensure control of the treatment efficiency.